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7-Keto DHEA is a powerful antioxidant that
aids fat metabolism and supports the production
of lean muscle tissue.
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u p p l e m e n t F a c t s |
| Serving
Size: 1 Capsule |
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Servings Per Container:
60 |
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Amount
Per Serving |
%
Daily
Value |
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7-keto DHEA |
50
mg |
† |
*
Percent Daily Values are based on 2,000 calorie
diet.
† Daily Value not established. |
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to
order
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7-keto DHEA (also called "7-oxo DHEA") is almost identical in structure to DHEA.
Human skin (and other tissues) contain enzymes that convert DHEA to 7-keto DHEA
in a two-stage process. (27) (Interestingly, many animal experiments with DHEA get best results if the DHEA is given
subcutaneously, hinting at skin DHEA bio-processing.) Research into 7-keto
DHEA has been conducted primarily by Dr. Henry Lardy and associates at the University of Wisconsin. (28, 29, 30)
Based on his research, Lardy has been granted various patents on the use of 7- keto
DHEA, including immune enhancement/modulation, Alzheimer's treatment and weight loss.
"7-keto DHEA has been
evaluated in both preclinical studies and human clinical trials for safety.
These studies show no mutagenic activity and no adverse effects for 7-keto DHEA
up to doses of 2000 mg /kg in rats and 500 mg /kg in primates. It should be
noted that 500 mg /kg is 3.5 grams in a normal 70 kg human." (30) Zenk notes
that a clinical trial conducted to measure the effects of 7- keto DHEA on
several endocrine and safety parameters in healthy adult men found 7- keto DHEA
to be safe and well-tolerated at doses up to 200 mg/day of a 28-day period.
(30) Zenk also reports that laboratory safety tests also showed 7- keto DHEA
does not affect haematology, serum chemistry, or urine chemistry differently
than healthy subjects taking placebo. (30)
Lardy has found that 7- keto DHEA (7-oxo-DHEA) is a potent increaser of liver
thermogenic enzymes. He reports that "The 7-oxo-derivatives of both DHEA [i.e.
7- keto DHEA] and androstenediol are the most active compounds tested. Over the
range of 0.01 to 0.1% of the diet, 7-oxo-DHEA was 2.5 times as active as DHEA."
(28) Research at the University of Wisconsin found 7- keto DHEA helpful in
treating primates infected with Simian Immunodeficiency Virus (SIV). CD-4 (T
helper) cell counts, CD-8 cell counts, and total white blood cells increased.
The SIV-infected primates also showed improvements in their physical state,
increased weight, and overall improvement in behavior and clinical condition.
(30)
7- keto DHEA was also shown to increase IL-2 production better than DHEA, in
human lymphocytes. IL-2 is the key cytokine regulator of T-helper cells, along
with interferon-gamma, which activates the immune system to "go into battle"
against invading pathogens. (30) Lardy and colleagues also found 7- keto DHEA to
enhance memory in 2-year old mice. "The mice were trained to negotiate a water
maze and then were given DHEA or 7-keto DHEA. They were retested after two
weeks. The control mice took 34 seconds [to negotiate the maze]; those on DHEA
took 22 seconds; and those on 7-keto DHEA took only 7.6 seconds.
Dr. Lardy found similar results in mice using scopolamine to abolish memory.
When protected with 7-keto DHEA [and given anti-memory scopolamine] the mice
were able to negotiate the water maze in 6.5 seconds, compared to 11.5 with DHEA
treatment and 22 seconds with scopolamine treatment only." (30).
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