Pyritinol

Pyritinol has been used clinically in a wide range of disorders including cerebral circulatory disorders, alcoholism, dyslexia, behavioral disorders in children, and stroke.

1. Pyritinol may be useful in various forms of dementia, head injury, stroke aftermath, coma, and cerebral circulatory disorders.
2. Pyritinol may be useful as an anti-brain aging, cognitive enhancing agent.
3. Pyritinol may be useful as an aid to improved memory, concentration, alertness and information processing in both young and old.
4. Pyritinol may be useful in Attention Deficit Disorder (ADD).
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Pyritinol has been used following head injury and cerebral trauma. Pyritinol has reduced the normal high death rate in such cases and has rapidly returned coma patients to more or less normal waking consciousness, even when the brain injuries were so severe the patient ultimately died.

Pyritinol has the ability to enhance glucose transport through the blood-brain barrier. Although the brain is usually less than 2% of total bodyweight, the brain uses about 20% of the body's total energy production. Under normal, non-fasting conditions, the brain can only 'burn' glucose (sugar) for fuel. Unlike virtually all other body cells, nerve cells cannot use fat as an energy fuel. Brain cells also cannot store any significant amount of glucose - they are completely dependent upon a continuous delivery of glucose from the blood, through the blood-brain barrier. Thus, brain glucose uptake is a major rate-limiting factor for crucial brain energy production. Pyritinol has the ability to increase glucose transport through the blood-brain barrier.