HYDERGINE®
LIQUID
Ingredients
Dihydroergotoxine mesylate
1 ml of drops in liquid (to be taken by mouth) =
1 mg dihydroergotoxine mesylate, 50 mg ethanol (96%), metansulphonic acid,
glycerine, demineralised water.
Properties
Experimental studies carried out on animals have
shown that dihydroergotoxine mesylate modifies cerebral neurotransmission,
stimulates dopaminergic and serotoninergic receptors and blocks alpha-adrenoreceptors.
It also improves diminished metabolic cerebral function; this effect can be seen
in modifications of the brain's electrical activity and particularly in the
energy spectrum of the electroencephalogram. This effect has also been confirmed
in the course of studies on man. It has furthermore been proven that
dihydroergotoxine mesylate reduces the time of cerebral circulation.
Indications
Controlled clinical assays have revealed that
dihydroergotoxine improves symptoms of mental deterioration related to ageing,
such as instability, dizziness, headaches, difficulty in concentrating,
disorientation, memory loss, lack of initiative, depression, lack of
sociability, difficulties in carrying out everyday activities and in personal
care. The role played by this medicine in the treatment of cerebrovascular
insufficiency has not been clearly established; it is merely symptomatic.
Dosage
Administration of this medicine must be
determined by a doctor according to the needs and response of each patient.
As a general rule, we recommend the
administration of 4.5 mg/day in a single dose or in separate doses to be taken
before meals (30 drops, 3 times daily). In certain cases, a 9-mg/day dosage may
be needed.
Contraindications
Hypersensitivity to the product. Patients with
acute or chronic psychoses of any etiology.
Precautions
Before beginning treatment, a complete diagnosis
should be carried out to exclude pathologies for which this type of substance
does not provide effective results (delirium, dementia).
This medicine should be used with caution with
severe bradycardia. Since it contains ethanol as an excipient, it may be prove
to be a risk if administered to patients with hepatic illnesses, alcoholism,
epilepsy, or to pregnant women and children.
Expectant and Nursing Mothers
Because of the lack of data available concerning
the effect that this pharmaceutical product may have on humans, avoid using it
except when absolutely necessary.
Adverse Effects
Although rare, these include nasal congestion,
nausea and gastric problems, which may be prevented by taking the pharmaceutical
product with food.
Such adverse effects tend to disappear with no
need to take specific measures.
It may cause skin irritation of an allergic
nature, headaches, reddening or blurred vision.
Incompatibilities
It may enhance the action of medicines for the
treatment of hypertension or those that lower cardiac rhythm (digitalis therapy,
beta blockers).
Intoxication and its Treatment
Accidental overdose may cause migraines, facial
reddening and nasal congestion and, in more serious cases, nausea and vomiting,
muscular weakness and significant hypotension. In extreme cases, it can cause
coma.
Symptomatic medication is to be aimed above all
at maintaining haemodynamic constants. Should the patient suffer from
hypotension, do not administer adrenalin, but rather noradrenaline or
angiotensin. In the event of overdose or accidental swallowing, consult the
Toxicology Information Service.
Available in: 40-ml container of drop solution
Keep this and all other medicines safely out of
the reach of children.
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